CRM Membrane for Erythromycin Production

Erythromycin is an alkaline antibiotic extracted from the broth of Streptomyces rubrum. It is a macrolide antibiotic，its antibacterial spectrum is similar to that of penicillin. Erythromycin has a strong inhibitory effect on Gram-positive bacteria.

In the downstream purification of erythromycin production, using its characteristics of dissolving in different solvents at different pH levels, repeated extraction with butyl acetate and aqueous solution to achieve the purpose of concentration and purification, and finally freeze crystallization in the butyl acetate solution to obtain high purity erythromycin. The filtration of erythromycin fermentation broth usually adopts zinc sulfate flocculation and plate and frame filtration extraction process. This process has disadvantages like serious heavy metal pollution, large amount of waste water, low filtration yield, high production cost, and light transmittance of the final product erythromycin thiocyanate .

With more than 20 years of experience in membrane separation, TANGENT has applied advanced ceramic membrane technology and nanofiltration membrane concentration technology to the clarification and concentration of erythromycin fermentation broth, replacing the traditional plate and frame filter press. The integrated membrane  extraction process has advantages like no heavy metal pollution, low waste discharge, high product yield, and good product quality. Tens of thousands of square meters ceramic membranes  filtration system have been widely used in erythromycin industry.

Process Diagram

Process Advantages
*No use of ZnSO4,No heavy metal discharge
*High yield of  Erythromycin
*Integrated Ceramic UF + NF membrane process
*Lower producing cost
*Waste discharge greatly reduced, kindly to environment
*High quality of Erythromycin
*Extraction process simplified
*Less contamination to  solvent extract
*Long work life of membrane
*Less labor and maintenance cost
*Better operational environment.